Since most of Prague’s major attractions are clustered together in the city’s Old and Lesser Town regions, it’s unlikely that you’ll require bus travel during your stay. For journeys which aren’t performed on foot, Prague’s extensive tram network is usually the preferred transportation method, although you may wish to travel by bus if you’re staying at some distance from the city centre.
All of Prague’s bus stations – including Na Knizeci, Repy and Cerny Most – connect to the main bus station: Florenc. From Florenc, you can transfer to the metro for a direct ride to the city centre. A transferrable ticket for both the bus and metro will set you back 32 CZK and lasts for 90 minutes after validation.
Buses 1 and 3 are special access vehicles which connect a number of Prague’s bus stations to Florenc, running regularly on weekdays. Despite the currently limited services for disabled tourists in Prague, the city is constantly striving to improve access for wheelchair-bound visitors.